Low-dose Gamma-irradiation Effect on Early Stage Development and Lifespan in Various Strains of Drosophila melanogaster / 대한산업의학회지

OBJECTIVES: Although ionizing radiation is recognized as being harmful to humans, debate continues regarding the effects of low doses of ionizing radiation. Some studies have reported that low doses of ionizing radiation have a bio-positive effect, namely hormesis, and many researchers have attempted to find concrete and scientific evidence to prove this. To determine whether the discrepancy in effects of low doses of ionizing radiation arises from genetic differences, a study with a multicellular organism system such as fruit flies is needed. METHODS: After irradiation at a low-dose rate of gamma radiation with chronic (0.2 Gy) and acute (0.2, 0.75 and 4 Gy), the pupa rate, eclosion rate and life span were examined with various wild type strains of Drosophila melanogaster such as W1118, Oregon-R, and Canton-S. RESULTS: The life span of Oregon-R exposed to both acute and chronic, low-dose radiation (0.2 Gy) was increased. Although there was some difference in the longevity between the acute and chronic radiation rate, no other differences were found. In Canton-S, only acute dose (0.75 Gy) increased the life span, but it did not in W1118. CONCLUSIONS: Although there were some differences between wild type fruit fly strains in longevity, the low doses of ionizing radiation extended the life span of D. melanogaster. Further studies need to be carried out to explain the difference according to dose and dose rate of radiation in the tested strains.

A Study on Rehabilitation Nursing Diagnoses used for the Clients with Stroke and Spinal Cord Injury in Korea / 재활간호학회지

The development of standards and guidelines of rehabilitation nursing has been the major concerns for providing better nursing to the rehabilitation clients. As the patients with stroke and spinal cord injuries are the most prevalent physical disabilities in Korea, this study focussed on the nursing diagnoses of these two groups of patients. In order to identify the nursing diagnoses frequently used in their practice for the patients with stroke and spinal cord injuries, a survey was done with the questionnaire form developed by the research team. The surveyee were the staff nurses working at rehabilitation wards more than 2 years from 8 general hospitals in Korea. They identified and set the priorities of 13 nursing diagnoses from 79 stroke patients and 10 nursing diagnoses from 35 patients with spinal cord injuries during the periods from March 1 to June 2, 1999. The identified nursing diagnoses for the stroke patients are impaired physical immobility, sensory-perceptual alterations, activity intolerance, self -care deficit, altered defecation, altered urination, risk for injury, unilateral neglect, impaired skin integrity, altered thought processes, pain, altered health maintenance, dysreflexia. The identified nursing diagnoses for spinal cord injuries are altered urination, altered defecation, impaired skin integrity, pain, risk for injury, reflex incontinence, impaired physical immobility, self-care deficit, activity intolerance, knowledge deficit.

The Validity of Nursing Diagnosis in Rehabilitation Nursing / 재활간호학회지

This study was conducted to investigate the nursing diagnosis applying to rehabilitation unit. The subject of this was consisted of 101 nurses who have been working over 1 year in rehabilitation unit. The clssification of nursing diag-nosis used NANDA's system and analysis of the validity was based on Fehring's model. In summury of this study, some dirrerences were found in related factors in nursing diagnosis between rehabilitation and general unit. Major re-lated factors of nursing diagnosis were physical factors associated with neuromuscular disorder. Valid related factors in altered nutrition: more than body requirements was not found for re-habitation unit. It is helpful for the nurses who work at re-habilitation unit to apply the nursing diagnosis validated in this study. This finding can be used as the database for accomplished nursing diag-nosis appropriate for improving the rehabilitation nursing practice.

The Study of Chromosomal Aberration in NSCLC Patients which Developed after Administration of Chemotherapeutic Agents / 대한암학회지

PURPOSE: Except hormonal agents and biologic response modifier, the biologic effects of chemotherapy and radiotherapy as anti-cancer therapy have the mechanism of DNA injury. They cause not only cancer cell necrosis, but also infertility, bone marrow suppression, secondary malignancy, and individual death. There are many reports to human genome or chromosomal injuries by radiation but few by chemotherapy. Therefore this study is designed for systemic evaluation of the frequency of chromosomal damage by chemotherapy. MATERIALS AND METHODS: We performed evaluation of chromosomal aberration, sister chromatid exchange, and mitotic index were examined in 3 patient with NSCLC. Two of them were stage IIIb and the other one was stage IV. Venous blood was taken from patients before chemotherapy and one day after last administration of combination chemotherapy. Microscopic examination for chromosomal aberration, chromatid aberration, and SCEs was done after cell culture and FPG stain. RESULTS: The incidence of chromatid break was 3 before chemotherapy and 26 after chemotherapy. The incidence of SCEs was 9.85 1.93 before chemotherapy and 40.47 7.12 after chemotherapy. CONCLUSION: Incidence of chromatid break and SCEs increased after combination chemotherapy.

Fatigue and the Related Factors in Well Women / 성인간호학회지

Fatigue is the subjective sense which people experience and use commonly in their lives. Although factors regards with fatigue have been explored in specific population, minimal study has been devoted to exploring associated variables generally healthy women. This descriptive study examined the relationship of demographic factors and depressions to subjective fatigue among women in the community who have no critical health problems. From June 15 to July 15, 1996, a convenience sample of 255 adult women completed the questionnaire which was developed by the author on the basis of Yoshitake's(1978) and Zung(1965), respectively. Pearson's correlation, t-test, ANOVA and Mann-Whitney test were used to analyze the data with SPSS/PC+ 5.0 for Windows. The results were as follows ; 1) Average fatigue score of the subjects was 12.57(+/-7.15)(range 0~30). Fatigue scores by area were neuroperceptive fatigue(4.81+/-2.90), physical fatigue(3.99+/-2.46) and mental fatigue(3.71+/-2.91) in order. Subjects with the fatigue scores more than 20 were forty four, 17.2 percent of total subjects. 2) Average depression score was 46.1(+/-6.96)(range 16~64), which was not so high. 3) Statistically significant relationship was noted between fatigue and depression scores(r=-.6747, p<.001) that means the more depressive, the more be fatigued. Correlations with respective fatigue area and depression were mental fatigue(r=-.6833, p<.001), neuroperceptive fatigue(r=-.5293, p<.001) and physical fatigue(r=-.5189, p<.001) in order. 4) Presence of disease revealed as the statistically significant variable affecting fatigue scores(t=-4.31, p<.001). Other variables such as age, marriage and job, however, had no statistically significant effect on the fatigue scores. Fatigue can meaningfully undermine quality of life in women who are accustomed to leading active lives. Fatigue is disabling, and a serious symptom to those who suffer from it. It is important for health providers as well as the women to recognize that there exits the relationship between fatigue and depression. Further investigation is necessary to facilitate adequate resolution of the clients' problem from fatigue leading to diminishment of the significance.